Prostate cancer treatment

Treatments can be given to cure cancer or to control or relieve symptoms. You may receive a single treatment or a combination of treatments based on your individual preferences/values and depending on the grade and stage of your cancer (i.e. how far the cancer has spread and how fast it can grow).

This section provides you with information on drugs to treat prostate cancer that are currently approved by Health Canada. As new prostate cancer drugs are approved for use in Canada we will update our information in a timely manner.

Approved by Health Canada

Drugs used in chemotherapy and radiotherapy

• Docetaxel (Taxotere)
• Cabazitaxel (Jevtana)
• Mitoxantrone (Teva)
• Prednisone ou Prednisolone
• Dichlorure de radium 223 (Xofigo)

Drugs used in hormone therapy

The most common LHRH agonists are:

• Leuprolide (Lupron, Lupron Depot, Eligard)
• Goséréline (Zoladex)
• Buséréline (Suprefact)
• Triptoréline (Trelstar)

The LHRH antagonist is:

• Dégarélix (Firmagon)

The most common types of anti-androgens are:

• Bicalutamide (Casodex)
• Flutamide (Euflex)
• Acétate de cyprotérone (Androcur)
• Nilutamide (Anandron)

Second line hormone therapy (new generation)

• Acétate d’abiratérone (Zytiga)
• Apalutamide (Erleada)
• Enzalutamide (Xtandi)
• Darolutamide (Nubeqa)

Drugs to treat bone metastases symptoms 

• Denosumab (Xgeva)
• Acide zolédronique (Zometa)
• Alendronate (Fosamax)
• Pamidronate (Aredia)

Newer targetted therapies 

• Olaparib (Lynparza)
• Lutetium (177Lu) (Pluvicto)

Newer nuclear imaging 

• TEP-PSMA (68Ga) (Illuccix)

Drugs to treat prostatitis

• Trimethoprime-sulfaméthoxazole
• Ofloxacine
• Ciprofloxacine
• Ampicilline
• Ciprofloxacine
• Doxycycline

Drugs to treat enlarged prostate

5-α-Reductase Inhibitors

• Finasteride (Proscar)
• Dutastéride (Avodart)

α-Blockers

• Tamsulosine (Flomax)
• Alfuzosine (Xatral)
• Silodosine (Rapaflo)
• Térazosine (Hytrin)
• Doxazosine (Cardura)

Drugs to treat incontinence

Anticholinergic

• Oxybutynin (Ditropan®) & (Ditropan XL®)*
  • (Oxytrol®)*
  • (Uromax®)
• Oxybutynin chloride gel (Gelnique®)
• Tolterodine (Detrol LA®) & (Detrol®)*
• Trospium chloride (Trosec®)
• Solifenacin (Vesicare®)
• Darifenacin (Enablex®)
• OnabotulinumtoxinA (Botox®)
• Fesoterodine (Toviaz®)
• Mirabegron (Myrbetriq®)

Tricyclic antidepressants

• Imipramine (Tofranil®)

*Médicaments les plus prescrits

Drugs to treat urinary tract infections

Fluoroquinolone – Quinolone

• Ciprofloxacine (Cipro®) & (Cipro XL®)
• Lévofloxacine (Levaquin®)
• Norfloxacine (Norflox®)
• Ofloxacine (Oflox®)
• Ampicilline

Sulfonamides

• TMP-SMX (Septra DS®)
• TMP (Apo-Trimethoprim®)

Others

• Nitrofurantoïne (Macrobid®)
• Nitrofurantoïne (Novo-Furantoin®)

β-lactamines

• Amoxicilline-clavulanate de K (Clavulin®)

Cephalosporins

• Cefadroxil (Duricef®)
• Cefprozil (Cefzil®)
• Cephalexine

Drugs to treat erectile dysfunction

Phosphodiesterase type 5 inhibitors

• Tadalafil
• Vardenafil
• Sildenafil

Drugs to treat hot flashes

• OEstradiol (EstroGel®)
  • (Alora®)
  • (Climara®)
  • (Dermestril®)
  • (Elleste Solo®)
  • (Esclim®)
  • (Menostar®)
  • (Vivelle-Dot®)
• Venlafaxine (Effexor®)
• Gabapentine (Neurontin®)
• Medroxy-progestérone (Provera®)
• Megestrol (Megace®)

For more information on medications reimbursed in Quebec, please visit the National Institute of Excellence for Health and Social Services (INESSS) website.