Approved drugs
Approved drugs
Treatments may aim to cure prostate disease or to halt or alleviate symptoms. You may receive a single treatment or a combination of treatments depending on your specific disease or symptoms, your age, and your overall health. Regarding prostate cancer, treatment will be based on the stage and grade of the disease you have, in other words, on the extent and pace of cancer spread.
This section provides information on medications currently approved by Health Canada. We will update this page as Health Canada approves new molecules for the treatment of prostate-related diseases, including cancer.
Drugs used in hormone therapy
The most common LH-RH analogues are:
- Leuprolide (Lupron, Lupron Depot, Eligard)
- Goserelin (Zoladex)
- Buserelin (Suprefact)
- Triptorelin (Trelstar)
The LH-RH antagonists are:
- Degarelix (Firmagon)
- Relugolix (Orgovyx)
The most common anti-androgens are:
- Bicalutamide (Casodex)
- Flutamide (Euflex)
- Cyproterone acetate (Androcur)
- Nilutamide (Anandron)
New generation of hormone therapy
- Abiraterone acetate (Zytiga)
- Apalutamide (Erleada)
- Enzalutamide (Xtandi)
- Darolutamide (Nubeqa)
Medications used in chemotherapy
- Docetaxel (Taxotere)
- Cabazitaxel (Jevtana)
- Mitoxantrone (Teva)
- Prednisone or Prednisolone
Medications used to treat symptoms related to bone metastases
- Denosumab (Xgeva)
- Zoledronic acid (Zometa)
- Alendronate (Fosamax)
- Pamidronate (Aredia)
Targeted therapies
- Olaparib (Lynparza)
- Niraparib/Abiraterone acetate (Akeega)
- Radium-223 dichloride (Xofigo)
- Lutetium (177Lu) (Pluvicto)
Nuclear imaging
- 68Ga PSMA PET (Illuccix)
5-α-reductase inhibitors
- Finasteride (Proscar)
- Dutasteride (Avodart)
α-blockers
- Tamsulosin (Flomax)
- Alfuzosin (Xatral)
- Silodosin (Rapaflo)
- Terazosin (Hytrin)
- Doxazosin (Cardura)
Anticholinergics
- Oxybutynin (Ditropan®) & (Ditropan XL®)*
- (Oxytrol®)*
- (Uromax®)
- Oxybutynin chloride gel (Gelnique®)
- Tolterodine (Detrol LA®) & (Detrol®)*
- Trospium chloride (Trosec®)
- Solifenacin (Vesicare®)
- Darifenacin (Enablex®)
- OnabotulinumtoxinA (Botox®)
- Fesoterodine (Toviaz®)
- Mirabegron (Myrbetriq®)
Tricyclic antidepressants
- Imipramine (Tofranil®)
*Most prescribed medications
Fluoroquinolone – Quinolone
- Ciprofloxacin (Cipro®) & (Cipro XL®)
- Levofloxacin (Levaquin®)
- Norfloxacin (Norflox®)
- Ofloxacin (Oflox®)
- Ampicillin
Sulfonamide
- TMP-SMX (Septra DS®)
- TMP (Apo-Trimethoprim®)
Others
- Nitrofurantoin (Macrobid®)
- Nitrofurantoin (Novo-Furantoin®)
β-lactams
- Amoxicillin-clavulanate K (Clavulin®)
Cephalosporins
- Cefadroxil (Duricef®)
- Cefprozil (Cefzil®)
- Cephalexin (Cephalexin®)
Erectile dysfunction
Inhibitors of phosphodiesterase type 5 or PDE-5
- Tadalafil
- Vardenafil
- Sildenafil
Penile injections
- Caverject
- TriMix
- QuadMix
MUSE Applicator*
*Out of stock in Canada
Additional Information - Treatment options
Sources and references
Last medical and editorial review: April 2024. See our web page validation committee and our collaborators by clicking here